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KMID : 0350519950480010139
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Journal of Catholic Medical College
1995 Volume.48 No. 1 p.139 ~ p.146
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Lysis of Experimentally Induced Intracerebral hematomas with Urokinase in Cats
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Abstract
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Urokinase, a potent thrombolytic agent, was tested in cats for safety and efficacy in lysing intracerbral hematomas. Intracerebral hematomas were created by stereotaxically injecting 1.5 ml of autologous blood clot into right basal ganglia of 32
anesthetized adult cats, each weighing 3.2 to 4.0 kg, through 22 gauge intravenous catheter.
Two control groups received 0.5 ml of normal saline into the clot. The group I (n=8) received saline into the clot at the 6 hours after blood clot injection. The group Ⅱ(n=8) received saline at the 24 hours. The other two groups,
urokinase-treated
groups, received equal volume of urokinase solution(5,000 unit). The groupⅢ(n=8) received urokinase solution into the clot at the 6 hours after blood clot injection. The groupⅣ(n=8) received urokinase solution at the 24 hours. All animals were
sacrified at the 24 hours after saline or urokinase injection. The remained clot was calculated asπ/6×Length×Width×Height(Ikeda et al., 1993).
The amounts of remained clots after lysing hematomas were as follows : 1.28±0.81 ml in groupⅠ, 1.37±0.05 ml in groupⅡ, 0.48±0.08 ml in groupⅢ, and 0.63±0.10 ml in groupⅣ. The results indicated that the urokinase-treated groups were more
lysing
hemetmas than the control group(P<0.05). But there was no significant difference in results between urokinase-treated at the 6 hours group(the groupⅢ) and the 24 hours group(the groupⅣ).
These results suggested that urokinase may be effectively and safely employed the lysis of intracerebral hematomas in cats.
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